Our research on full-conditioning

International prices

Frame Left Jerome Hoffman price AAGL 2001
1st Prize Belgian Soc Reprod Medecine 2001 Molinas 2001

1st Prize ESGE R. Palmer 2001 Molinas

1st Prize ESHRE Promising scientist award 2002 Molinas
AAGL 2002 : Ospan Mynbaev

1st Prize ESGE Cagliari 2004 Binda
Frame Left ASRM 2004 Distinguished Surgeon award P Koninckx

The mechanisms of peritoneal damage

Frame right Frame right The sum of all good and bad factors will determine the degree of acute inflammation of the entire peritoneal cavity. These are : Duration of surgery, degree of manipulation, desiccation, hypoxia, reactive oxygen species, blood, fibrin and all irritating substances.

The consequences: mesothelial cell retraction and acute inflammation

Frame rightThe direct consequence of peritoneal irritation is retraction of the mesothelial cells exposing directly the underlying intercellular matrix. The consequences are
  • progressively increasing CO2 resorbtion during surgery
  • acute inflammation and later inflammation of the entire peritoneal cavity.
  • postoperative pain
  • slower recovery
  • enhanced adhesion formation at surgical trauma sites
  • deeper ischemia and decreased ovarian reserve
  • enhanced risk of bowel perforation or leaks

The prevention of peritoneal damage

Prevention of peritoneal damage is the cumulative effect of protection and of avoiding damage
  • Surgery of short duration with little trauma and little blood loss is obvious
  • The addition of N2O to the CO2 pneumoperitoneum is the single most important. That small doses are sufficient was unexpected.
  • Cooling of the peritoneal cavity to make cells more resistant to trauma.
  • Cooling of the peritoneal cavity and humidification can prevent completely desiccation.
  • Prevent fibrin deposition with heparin
  • dexamethasone at the end of surgery

Images of adhesions

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